abstract：:The purpose of this study was to evaluate the mortality experience of persons with longstanding diabetes who had received pituitary irradiation for diabetic retinopathy compared to a matched group of persons with diabetes who had not had pituitary ablation. The irradiated cohort consisted of 167 patients treated at th...

journal_title：Journal of diabetes and its complications

authors： Klein BE,Linfoot JA,Nakagawa JS,Lee KE

更新日期：1998-09-01 00:00:00

abstract：:The endocrine cells in the duodenum of pre-diabetic and diabetic female non-obese diabetic (NOD) mice aged 22-24 weeks were studied by means of immunohistochemistry and computed image analysis as well as by radioimmunoassays of tissue extracts. As controls, 12 female BALB/cJ mice of the same age as NOD mice were used....

journal_title：Journal of diabetes and its complications

authors： El-Salhy M,Zachrisson S,Spångéus A

更新日期：1998-07-01 00:00:00

abstract：:Vasomotion, the spontaneous rhythmic contraction exhibited by small arteries and arterioles is dysregulated in patients with diabetic neuropathy. We examined the relationship between Charcot arthropathy and vasomotion at the dorsum of the foot. We studied nine diabetic patients with clinically diagnosed neuropathy and...

journal_title：Journal of diabetes and its complications

authors： Shapiro SA,Stansberry KB,Hill MA,Meyer MD,McNitt PM,Bhatt BA,Vinik AI

更新日期：1998-05-01 00:00:00

abstract：:The aim of our study was to compare ambulatory blood pressure monitoring (ABPM) measures (mean systolic/diastolic blood pressure, diurnal rhythm, and pressure burden) in matched normo- and microalbuminuric (IDDM) adolescents and healthy controls. Twenty-four hour monitoring was undertaken in 39 normotensive (normal cl...

journal_title：Journal of diabetes and its complications

authors： Sochett EB,Poon I,Balfe W,Daneman D

更新日期：1998-01-01 00:00:00

abstract：:A changed vasomotor reactivity of renal arteries may lead to defect autoregulation of renal hemodynamics with damage of diabetic kidneys. Eleven streptozotocin-induced diabetic male Wistar rats were daily treated with insulin in order to achieve a blood glucose of 21 mmol/L. Seventeen age and gender-matched rats serve...

journal_title：Journal of diabetes and its complications

authors： Torffvit O,Adamsson M,Edvinsson L

更新日期：1997-09-01 00:00:00

abstract：:In patients with insulin-dependent diabetes mellitus (IDDM), albuminuria reflects widespread vascular dysfunction. Albuminuria has been associated to defects of heparan sulfate proteoglycan (HSPG) within the extracellular matrix. Our hypothesis is that loss of HSPG in vascular walls reduces the HSPG-bound lipoprotein-...

journal_title：Journal of diabetes and its complications

authors： Hansen PM,Jensen T,Egeberg J,Lithell H,Kofoed-Enevoldsen A,Deckert T

更新日期：1997-07-01 00:00:00

abstract：:The role cardiac autonomic neuropathy (CAN) plays in diabetes is not well known. The aim of this study was to identify the factors involved in CAN in diabetic patients. One hundred patients, 44 insulin-dependent (IDDM) and 56 non-insulin-dependent (NIDDM), were investigated, using five standard tests. Three of these t...

journal_title：Journal of diabetes and its complications

authors： Valensi P,Huard JP,Giroux C,Attali JR

更新日期：1997-05-01 00:00:00

abstract：:Non-insulin-dependent diabetes mellitus (NIDDM) is associated with approximately two fold increase in coronary heart disease (CHD) in men and fourfold increase in CHD in women. In most studies, the duration of diabetes and severity of glycemia are only weakly related to CHD in NIDDM, suggesting that the prediabetic pe...

journal_title：Journal of diabetes and its complications

authors： Haffner SM

更新日期：1997-03-01 00:00:00

abstract：:Lipid and lipoprotein abnormalities in non-insulin-dependent diabetes mellitus (NIDDM) include particularly elevated levels of total and very-low-density lipoprotein (VLDL) triglycerides and reduced levels of high-density lipoprotein (HDL) cholesterol. Total and low-density lipoprotein (LDL) cholesterol levels are usu...

journal_title：Journal of diabetes and its complications

authors： Laakso M

更新日期：1997-03-01 00:00:00

abstract：:The aim of this study was to determine the factors associated with diabetic peripheral neuropathy and more particularly its relation to precisely assessed microangiopathy. Peripheral neuropathy was assessed in 135 diabetic patients: 28 insulin-dependent diabetes mellitus (IDDM), 85 non-insulin-dependent diabetes melli...

journal_title：Journal of diabetes and its complications

authors： Valensi P,Giroux C,Seeboth-Ghalayini B,Attali JR

更新日期：1997-01-01 00:00:00

abstract：:The mechanism(s) resulting in the premature atherosclerosis of diabetes is unknown. Increased phagocyte release of reactive oxygen species such as superoxide anion (O2.-), resulting in low-density lipoprotein (LDL) oxidation, could be one possible cause. The purpose of the present study was to compare the abilities of...

journal_title：Journal of diabetes and its complications

authors： Fuller CJ,Agil A,Lender D,Jialal I

更新日期：1996-07-01 00:00:00

abstract：:Table 1 shows how the five major drug groups interact with those variables which should be especially considered when treating the hypertensive diabetic. While diuretics are sometimes required in severely hypertensive cases-particularly when fluid retention is part of the clinical picture, and beta blockers are the ou...

journal_title：Journal of diabetes and its complications

authors： Poulter NR

更新日期：1996-05-01 00:00:00

abstract：:Malignant external otitis (MEO) is an infection of the external auditory meatus, that affects elderly diabetic patients. As this disease results in a high percentage of deaths, especially if the diagnosis is delayed, we thought that it would be useful to cite a recent case study that was resolved in a positive way, in...

journal_title：Journal of diabetes and its complications

authors： Manfrini S,Gregorio F,Capoolicasa E

更新日期：1996-01-01 00:00:00

abstract：:This study was designed to investigate the effects of the calcium channel blocker manidipine on insulin-dependent glucose uptake (insulin sensitivity) and insulin action to renal sodium handling and pressor systems in essential hypertensive (EHT). Seven EHT were hospitalized and a 2-h euglycemic hyperinsulinemic gluco...

journal_title：Journal of diabetes and its complications

authors： Iimura O,Shimamoto K,Masuda A,Higashiura K,Miyazaki Y,Hirata A,Fukuoka M,Murakami H

更新日期：1995-10-01 00:00:00

abstract：:Increased extracellular matrix (ECM) is the ultrastructural hallmark of diabetic microangiopathy. Its accumulation within the kidney is directly linked to the clinical manifestations of diabetic nephropathy, namely proteinuria and declining renal function. The pathogenesis of ECM changes in diabetes is not well unders...

journal_title：Journal of diabetes and its complications

authors： Gilbert RE,Cox A,Dziadek M,Cooper ME,Jerums G

更新日期：1995-10-01 00:00:00

abstract：:In order to elucidate the role of macrophage in lipid-induced nephrotoxicity in diabetic nephropathy, we examined the effect of macrophage colony-stimulating factor (M-CSF) on the progression of renal lesions in hypercholesterolemic steptozotocin (STZ)-diabetic rats fed with high cholesterol chow. Hypercholesterolemia...

journal_title：Journal of diabetes and its complications

authors： Utsunomiya K,Ohta H,Kurata H,Tajima N,Isogai Y

更新日期：1995-10-01 00:00:00

abstract：:Abnormalities of renal prostaglandins (PGs) contribute to the pathogenesis of diabetic nephropathy through changes in renal hemodynamics. Our recent studies have demonstrated that urinary excretion ratio of 6-keto-PGF1 alpha (6KF) to TXB2 is decreased in patients with non-insulin-dependent diabetes mellitus (NIDDM). I...

journal_title：Journal of diabetes and its complications

authors： Umeda F,Kuroki T,Nawata H

更新日期：1995-10-01 00:00:00

abstract：:The long-term effects of angiotensin-converting enzyme inhibitors (captopril and enalapril), calcium-entry blockers (diltiazem and nicardipine), and good glycemic control on plasma lipids and lipoproteins were studied in streptozotocin diabetic rats. Diabetic rats had increased plasma cholesterol, tryiglycerides, very...

journal_title：Journal of diabetes and its complications

authors： Reddi AS,Jyothirmayi GN,Bollineni JS

更新日期：1995-07-01 00:00:00

abstract：:We randomized 102 patients with insulin-dependent diabetes to intensified treatment (n = 48 at baseline, n = 42 after 7.5 years) or standard treatment (n = 54 at baseline, n = 47 after 7.5 years). As has previously been reported, intensified treatment resulted in a retardation of retinopathy, nephropathy, and neuropat...

journal_title：Journal of diabetes and its complications

authors： Reichard P

更新日期：1995-01-01 00:00:00

abstract：:Non-insulin-dependent diabetes mellitus (NIDDM) is associated with an increased risk of macro- and microvascular degenerative complications. Gliclazide is a second generation sulfonylurea that is widely used in the treatment of type II diabetes mellitus. Its hypoglycemic activity is well documented. In addition to its...

journal_title：Journal of diabetes and its complications

authors： Ziegler O,Drouin P

更新日期：1994-10-01 00:00:00

abstract：:The prevalence and determinants of urinary albumin excretion rate (AER) were assessed in lean and overweight normotensive subjects (NT) and patients with essential hypertension (EH). In NT and EH, the presence of overweight was associated with a significant exacerbation of AER. In the normotensive population, AER was ...

journal_title：Journal of diabetes and its complications

authors： Mimran A,Ribstein J,DuCailar G,Halimi JM

更新日期：1994-07-01 00:00:00

abstract：:Fifty-six type I diabetic patients with microalbuminuria (albumin excretion rate 20-200 micrograms/min) were characterized as to sex, age, duration of diabetes, smoking habits, blood pressure, glomerular filtration rate, urinary NC1 (the carboxy-terminal domain of collagen IV), and Tamm-Horsfall protein excretion rate...

journal_title：Journal of diabetes and its complications

authors： Torffvit O,Agardh CD

更新日期：1994-04-01 00:00:00

abstract：:Tolrestat is a well tolerated nonhydantoin aldose reductase inhibitor that has been reported to improve nerve conduction in diabetic animals and humans. Its effects on nerve biochemistry and structure have not been studied in patients with diabetic neuropathy. Patients with advanced diabetic neuropathy treated with lo...

journal_title：Journal of diabetes and its complications

authors： Sima AA,Greene DA,Brown MB,Hohman TC,Hicks D,Graepel GJ,Bochenek WJ,Beg M,Gonen B

更新日期：1993-07-01 00:00:00

abstract：:Intact lenses from New Zealand white rabbits were incubated in tissue culture media containing either 5 mM glucose or 5 mM glucose plus 30 mM galactose. The standard media did not contain taurine. Lenses were also cultured in a third medium containing 30 mM galactose plus 0.2 mM taurine. The frequency of cataract form...

journal_title：Journal of diabetes and its complications

authors： Malone JI,Benford SA,Malone J Jr

更新日期：1993-01-01 00:00:00

abstract：:We examined the potential of astemizole, a histamine H1-receptor antagonist that does not cross the blood-brain barrier, to reverse blood-retinal barrier leakage to albumin in streptozotocin diabetic rats. Four groups of nondiabetic and four groups of diabetic rats received vehicle or astemizole at dosages of 5, 10, o...

journal_title：Journal of diabetes and its complications

authors： Hollis TM,Sill HW,Butler C,Campos MJ,Gardner TW

更新日期：1992-10-01 00:00:00

abstract：:In a group of 46 consecutive outpatients attending the diabetic clinic of our Metabolic Department, 30 insulin-dependent and 16 non-insulin-dependent diabetic patients in stable metabolic control, and in 38 age-matched controls, we measured vibration perception threshold with biothesiometer and autonomic function, by ...

journal_title：Journal of diabetes and its complications

authors： Piaggesi A,Castro Lòpez E,Bini L,Benzi L,Giampietro O,Schipani E,Navalesi R

更新日期：1992-07-01 00:00:00

abstract：:Paecilomyces is a saprophytic soil fungus that is an uncommon human pathogen. We report a diabetic patient who developed an upper lobe pulmonary infection due to Paecilomyces varioti. This pneumonia responded poorly to oral imidazole therapy with ketoconazole. Eventual treatment of the chronic infiltrating process req...

journal_title：Journal of diabetes and its complications

authors： Byrd RP Jr,Roy TM,Fields CL,Lynch JA

更新日期：1992-04-01 00:00:00

abstract：:Although the etiology of diabetic neuropathic pain remains enigmatic, two types of neuropathic pain are now recognized: nerve trunk pain following a discrete often vascular lesion as seen in ocular mononeuropathy and hyperalgesic pain as seen in diffuse involvement of peripheral sensory fibers. Our understanding of th...

journal_title：Journal of diabetes and its complications

authors： Boulton A

更新日期：1992-01-01 00:00:00